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[6] [10] Both ultimately rely primarily on passive diffusion for absorption

Oxidative stress (OxS)/cellular damage Oxidative stress (OxS) is a nonspecific pathophysiological condition that reflects a redox imbalance between increased production of ROS (free radicals) and the inability of antioxidant defenses to neutralize the reactive intermediates or to repair the ensuing damage 179,180

Local side effects: Common local side effects of nasal spray may include temporary nasal irritation or dryness, and occasional nosebleeds with prolonged or excessive use [14]

Our report underscores the important role of nuclear glutathione in cell physiology and suggests that manipulation on nuclear GSH levels could be of paramount importance during development and cancer