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Conceptually, co-targeting lactate handling (LDH/MCTs) together with chromatin writing (p300/CBP) may be rational in lactate-high tumors or therapy-induced lactate rebound contexts, but it should be framed as a strategy to re-shape lactate-driven transcriptional and microenvironmental states, supported by orthogonal pharmacodynamic readouts (for example, site-specific Kla quantified by mass spectrometry or rigorously validated antibodies)

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