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They seem to be well tolerated in patients with mild and moderate liver function impairment, though they should be cautiously administered in patients with advanced liver disease.77,78 SGLT2 inhibitors Selective renal sodium glucose co-transporter 2 (SGLT2) inhibitors improve glycemic control in an insulin-independent fashion through inhibition of glucose reuptake in the kidney.79 The most used drugs from this group are: dapagliflozin, canaglifozin and empaglifozin

Yet, this remains highly speculative

Measurements of membrane currents were obtained using an EPC-9 amplifier controlled using PatchMaster software (HEKA Electronik, Lambrecht/Pfalz, Germany)