GLP-1 is likely best described as a neuropeptide with physiologically and pharmacologically relevant effects on food intake and body weight (116, 117), potential neuromodulatory roles, and possible effects in a range of other neuropathological conditions including neurodegenerative diseases (e.g., Alzheimer's, Parkinson's), brain trauma and stroke, as well as in depression, anxiety and addiction (118123)
When a person is stressed or anxious, the bodys fight-or-flight response can be triggered, leading to sweating
Importantly, these agonists feature extended half-lives compared to melatonin, making them more suitable for sustained in vivo applications
Other meta-analyses, however, despite showing that patients with BD present lower peripheral levels of tryptophan, Kyn or KYNA, did not find any significant differences between manic and depressed phases [230]