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Sample size and power calculations in Mendelian randomization with a single instrumental variable and a binary outcome

After fatty infiltration of the pancreas, beta ()-cell dysfunction was tightly connected to the presence and severity of NAFLD creating a vicious-cycle of a feed-forward effect [19, 20]

Anything below or above this range is considered to be at the extreme end of the spectrum: BMIs under 18 are in the underweight range, while those over 30 are in the obese range