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Licensed options in the UK include orlistat (oral), semaglutide 2.4 mg (Wegovy, approved by NICE TA875 for eligible patients), and tirzepatide (Mounjaro for type 2 diabetes

Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations

If someone treats it as a free pass to overeat other high-calorie foods, the calorie savings can disappear

How Dose Titration Minimizes Side Effects To make the treatment as manageable as possible, providers use a strategy called dose titration