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Cancer Immunol Res 7(10):16051618 Xia HL, Lv Y, Xu CW et al (2017) MiR-513c suppresses neuroblastoma cell migration, invasion, and proliferation through direct targeting glutaminase (GLS)

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The first is the antioxidant barrier: polyphenols establish antioxidant defense by activating the Nrf2 signaling pathway, and Nrf2 upregulates the expression of HO-1, SOD-1, NQO-1 and other oxidative genes, so as to increase the number of antioxidant enzymes (SOD/CAT/GPX/GSH), and to neutralize cisplatin-induced reactive oxygen species (ROS) and reactive nitrogen species (RNS)