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Risk factors include renal impairment, concomitant use of certain drugs, age 65 years old, radiological studies with contrast, surgery and other procedures, hypoxic states, excessive alcohol intake, and hepatic impairment

Despite important procedural differences from our present study, a closer look at their findings also reveals a strong initial anorectic effect of Ex in the first 1 to 3 h, and the food consumption reductions in the time period of 4 to 5 h post-administration were of comparable size to our present findings in S2