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10.1093/infdis/jiu017 Summary Keywords voriconazole, hepatotoxicity, acute liver injury, therapeutic drug monitoring, trough concentration Citation Ren J, Cai X, Ge W, Guo J, Wang S, Wang Q, Liu L, Yang L and Yang Q (2025) Risk factors for voriconazole-associated hepatotoxicity in patients with liver dysfunction: a retrospective nested casecontrol study

Liver dysfunction does not explain every mood or cognitive symptom, but oxidative stress, altered medication metabolism, gut-derived inflammation, ammonia, copper imbalance, low glutathione and impaired methylation may reduce neurological resilience in selected patients

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