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highlight, in both groups, a general clinical improvement, with positive effects on pain and depressive symptoms, but neither induced a significant improvement in anxiety

The pivotal programs are public, the STEP trials for semaglutide in weight management ( The New England Journal of Medicine , 2021), SURMOUNT for tirzepatide in weight management (NEJM, 2022), and SURMOUNT-OSA for tirzepatide in obstructive sleep apnea (NEJM, 2024)

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This medication has become one of the most studied weight loss therapeutics available