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Discontinuing any GLP-1 therapy requires careful tapering, metabolic support, and often a bridge medication to prevent the dramatic appetite rebound that typically follows abrupt cessation

Upregulation of melanogenesis and tyrosinase activity: potential agents for vitiligo

Candidates include adults who have struggled to lose weight through diet and exercise alone, those with a BMI in the overweight or obese category, and patients seeking physician-supervised alternatives to surgical procedures

This framework helps distinguish whether an individual has actual nutrient insufficiency, mitochondrial stress, or metabolic dysfunction that might benefit from component-level support versus lifestyle intervention alone