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Upper/Lower Gastrointestinal Symptoms Adverse event reporting databases, RCTs, and real-world data consistently show that GLP-1 RAs are commonly associated with GI symptoms such as nausea, vomiting, diarrhea, constipation, abdominal pain, and dyspeptic complaints

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280 The small sample sizes, heterogeneity in L-carnitine route of administration and dose, variable durations of study and methods of analysis, and the inclusion of patients with normal triglyceride levels in most studies make interpretation of these data difficult

G-Protein-Coupled Receptor (GPCR) Signaling and Pharmacology in Metabolism: Physiology, Mechanisms, and Therapeutic Potential