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Conversely, chronic disease states such as hypertension or hyperglycemia generate reactive oxygen species that further exacerbate mitochondrial damage, creating a self-perpetuating cycle

S., Constantinescu, S

The Impact of Environmental Factors on the Secretion of Gastrointestinal Hormones

Some investigators have proposed that GLP-1RAs improve myocardial insulin sensitivity, enhance glucose oxidation rates, reduce fatty acid oxidation, and thereby optimize myocardial energy metabolism, ultimately improving cardiac function