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This marks the first time a regulatory authority has formally acknowledged the link, following multiple studies suggesting an increased risk of NAION among type-2 diabetes patients taking semaglutide

Beyond proteasomal targeting, non-canonical ubiquitin modifications, including K63-linked polyubiquitination, regulate signaling, endocytosis, kinase activity, and DNA damage responses, while mono- and multi-ubiquitination influence chromatin dynamics, DNA repair, and subcellular localization (Fig

But it does mean that the next 90 days are an opportunity, not a countdown

But they dont treat the root cause, and theyre only supposed to be used in the short term