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With tirzepatide, the usual starting dose is 2.5 mg once weekly, with increases every ~4 weeks if tolerated, up to a maintenance dose of 5-15 mg weekly for weight loss

Clinical investigations have yielded mixed results, with the LixiPark trial demonstrating potential disease-modifying effects in patients with early Parkinsons disease, showing slower motor symptom progression compared to the placebo group [115]

The overall results show that GLP-1 RAs were successful in decreasing BMI, lesion severity and presence, and inflammatory markers while also increasing quality of life