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They present a dual functionality, transitioning between the inflammatory M1 state and the anti-inflammatory M2 state

If they are going to be used they should be made according to a USP monograph or be a component of an approved drug, if no monograph exists it must be on the 503A Bulk List, and it must be manufactured in an FDA registered facility with a proper certificate of analysis

And it allows agencies to condense much of the process into a written report, which they would then share with third parties for review instead of consulting them along the way

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