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While proteasomal dysfunction has been extensively studied in the context of aging and age-associated pathologies 2,3,57,58,59,60,61 , upstream regulators of ubiquitin turnover, such as deubiquitylating enzymes (DUBs), remain less explored

Nrf2 regulation by curcumin: molecular aspects for therapeutic prospects

The mechanism likely involves GLP-1 receptors found directly in joint tissue, with liraglutide shown to reduce matrix metalloproteinases (enzymes that break down cartilage) and shift macrophages in the joint to an anti-inflammatory state [19]