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Three weeks in advance of the change, we communicated with patients to educate them about CVS Caremarks update

This assessment is even more relevant if it is considered that the oxidized state would lead to an intramolecular disulfide bond, which usually could not lead to a single reduced Cys residue under reducing conditions, but must allow two bonds with mPEG-MAL, unless the second Cys residue is structurally or spatially hidden

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And, most importantly, this increase occurred rapidly (within hours) [9]