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10.1007/s00125-021-05590-5 Summary Keywords sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide 1 receptor agonists, renal outcome, combination therapy, preceding drug, diabetic kidney disease Citation Muta Y, Kobayashi K, Toyoda M, Tone A, Suzuki D, Tsuriya D, Machimura H, Shimura H, Takeda H, Yokomizo H, Takeshita K, Chin K, Kanasaki K, Tamura K, Miyauchi M, Saburi M, Morita M, Yomota M, Kimura M, Hatori N, Nakajima S, Ito S, Tsukamoto S, Murata T, Matsushita T, Furuki T, Hashimoto T, Umezono T, Takashi Y and Kawanami D (2024) Influence of the combination of SGLT2 inhibitors and GLP-1 receptor agonists on eGFR decline in type 2 diabetes: post-hoc analysis of RECAP study

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CagriSema vs Tirzepatide (REDEFINE 4): strong weight loss, but an important endpoint miss Novo Nordisk has announced headline results from the open-label phase 3 REDEFINE 4 trial comparing CagriSema (cagrilintide + semaglutide) vs tirzepatide 15 mg in obesity

That being said, the symptoms can be devastating and cause a decrease in quality of life