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The largest trial included older patients (mean age 72.4 years) (S1 Table)

While we lack definitive RCT data, there is a strong physiological rationale and emerging real-world experience suggesting benefits from tapering doses (e.g., 15 12.5 10 2.5 mg) before stopping: Allows neurohormonal pathways to recalibrate gradually rather than abruptly Provides a window to stabilize lifestyle adjustments at each step May help identify a lowest effective maintenance dose that sustains satiety signals Reduces the shock of withdrawal, lowering the risk of rapid rebound Key takeaway: The narrative that all patients regain weight after GLP-1/GIP therapy overlooks an important nuance: regain has been observed when treatment is stopped suddenly at high doses

Celebrex (celecoxib) is a prescription NSAID manufactured by Pfizer, approved to treat: Osteoarthritis Rheumatoid arthritis Juvenile rheumatoid arthritis (2+ years old) Ankylosing spondylitis Acute pain (e.g., back pain) Primary dysmenorrhea (menstrual cramps) It is a COX-2 inhibitor that reduces prostaglandin production to relieve inflammation and pain