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This review organizes nanoplatforms through a tumor microenvironment phenotype-informed design logic that links biological barriers to design objectives, module choices, measurable readouts, evidence strength and translational constraints

Its primary function involves degrading reduced GSH, thereby disrupting GSH redox balance and shifting the cell towards a more oxidized state

Before cellular enzymes can even reach a site of DNA damage, glutathione acts as a rapid, first-line chemical repair agent

Jha S, Halder M (2023) Medicinal plants and bioactive phytochemical diversity: a fountainhead of potential drugs against human diseases