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Despite its strengths as a well-designed human intervention study, the follow-up period was relatively short, limiting conclusions regarding durability of glycemic improvements, long-term insulin resistance trajectories, or effects on clinically meaningful outcomes such as diabetes progression, medication requirements, or cardiovascular risk

doi: 10.1111/imr.12160 39 YueXTrifariSijTTsagaratouAPastorWAZepeda-MartnezJAet al

Better Retention Compared to Other Forms Some studies suggest the methylated form of B12 may have longer tissue retention than non-methylated forms, supporting ongoing B12 status

Animal models reinforce intermittent use In the same mouse studies, repeating monthly Epitalon cycles increased maximum lifespan and improved genomic stability