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5.4 Optimization of cardioprotective effects: Scientific framework and strategic considerations To effectively harness the cardioprotective potential of probiotics, prebiotics, and their synbiotic combinations, a multidimensional optimization strategy is required encompassing strain selection, delivery matrix, synergy with bioactives, and targeted modulation of host-microbe pathways

Cell Physiol Biochem 56:2435 Al-Dwairi A, Alqudah TE, Al-Shboul O, Alqudah M, Mustafa AG, Alfaqih MA (2019) Glucagon-like peptide-1 exerts anti-inflammatory effects on mouse colon smooth muscle cells through the cyclic adenosine monophosphate/nuclear factor-B pathway in vitro [Corrigendum]

Traditional treatments such as topical creams and oral medications often provide only partial relief, leading many individuals to explore alternative therapies