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Stopping semaglutides tends to lead to weight regain in many people, and studies have shown that a large portion of patients gain weight after stopping semaglutide

Common adverse effects are predominantly gastrointestinal and typically emerge during dose escalation: Nausea (affecting 2050% of users initially) Vomiting and diarrhoea Constipation Abdominal pain and bloating Reduced appetite (therapeutic effect but may be excessive) Fatigue and headache Injection site reactions (redness, swelling or itching) These effects usually diminish over several weeks as the body adjusts

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2024;Volume 18:373-382