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Additionally, the presence of nitric oxide (NO) can competitively inhibit cytochrome c oxidase, a key enzyme in the mitochondrial respiratory chain, further modulating oxygen consumption and influencing tissue oxygenation, particularly in conditions like heart failure (PrezRojas & Muriel, 2005

Notable observations post-administration include a marked increase in daytime activity, the erasure of circadian rhythms ( Pharmacological intervention Experimental groups were established, each comprising 6 model mice and 6 control mice