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Proposed mechanisms include improvements in endothelial function, reduction in systemic inflammation, favourable effects on blood pressure and lipid profiles, and direct actions on cardiac and vascular tissues expressing GLP-1 receptors

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Despite promising results from existing randomized controlled trials of semaglutide and tirzepatide in those with obesity-related HFpEF, regulatory authorities and professional societies have not approved or endorsed the use of these drugs for HFpEF, due in part to the studies relatively small sample sizes and unknown generalizability