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To note, Pinchera et al

& Gardella, T

Those presenting with anxiety, insomnia, panic attacks, brain fog, and mood swings, particularly when symptoms flare in response to food, supplements, or stress, often have underlying neuroimmune activation

As an alternative approach to improve in vivo stability of the fusion molecule, we then engineered a disulphide bridge into the exendin-4 peptide moiety (Ab#2_DSB#1) as this has been shown to improve in vitro and in vivo stability of both GLP-1 and exendin-4 analogue peptides 36