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A large-scale whole-genome meta-analysis of serious autoimmune T2DM (research object = 452, control = 2,744) and focal epilepsy (research object = 929, control = 212,532) in Europeans revealed that genetic susceptibility to severe autoimmune T2DM was associated with an increased risk of focal epilepsy (83)

Half of those are likely NOD candidates with 1% of NOD individuals at a higher risk for PDAC diagnosis ( Figure 1B ) ( Figure 1 Although it is well established that a small proportion of patients with NOD have an increased risk of subsequently being diagnosed with PDAC, translating this association into a broadly applicable clinical strategy remains challenging

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We report that IFN- skews antigen presentation in favor of HLA-B-restricted peptides, including both conventional and alternative antigens, which are recognized by islet-infiltrating CD8 + T cells of T1D patients