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In addition, neuroinflammation causes immune cells (monocytes and lymphocytes in the blood, such as T cells and B cells) to infiltrate the central nervous system from the periphery across the BBB, accelerating neuroinflammation and neurodegeneration (49, 50)

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Telomeres are protective caps at the ends of chromosomes that shorten with cell division

Urinary Proteome Analysis The total protein concentration was measured in each sample using a BCA Protein Assay Kit (Thermo Scientific) at an absorbance of 570 nm and referenced to a standard curve