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There is insufficient clinical trial data to confirm their efficacy and safety in humans

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Two of the field-defining dihexa papers from the Journal of Pharmacology and Experimental Therapeutics were formally retracted in April 2025 for falsified and fabricated image data, with the retraction attributing the misconduct to Leen Kawas and James Harding (retraction record

To obtain the specific labeling patterns, intracellular metabolites were extracted and analyzed using GC/MS to determine multiple ion detections (MIDs) (corrected for natural isotope abundance), which reflect relative metabolic fluxes 28