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Habener, Mojsov, and Knudsen at the 2025 Friends of the NLM Awards Gala , to be held on September 8, 2025, at the Willard Intercontinental Hotel in Washington, DC

It is a triple agonist, targeting GLP-1, GIP, and glucagon receptors, three separate hormonal pathways working simultaneously to suppress appetite, accelerate fat metabolism, and improve insulin sensitivity

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For example, activation of the MAPK pathway can upregulate DNA repair factors such as XRCC1 and RAD51, thereby enhancing resistance to agents like mitomycin C [64]