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As of December 2023, she said she was just seven pounds away from her 160-pound goal even though she insists "it's not about the number." "An Oprah Special: Shame, Blame and the Weight Loss Revolution" airs March 18 on ABC at 8 p.m

7 In pancreatic -cells, GLP-1R activation by semaglutide enhances glucose catabolism and insulin secretion via the mTOR-dependent HIF-1 pathway, facilitating glycolysis and insulin release

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