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Neuroinflammation and apoptosis are common causes of FPN-induced neuronal damage, indicated by caspase-3 activation, glial fibrillary acidic protein (GFAP) upregulation, inducible nitric oxide synthase overexpression, and neuronal degeneration 2,14

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Nature 387 : 299303 Lee YI, Han YJ, Lee SY, Park SK, Park YJ, Moon HB, Shin JH, Lee JH (2003) Activation of insulin-like growth factor II signaling by mutant type p53: physiological implications for potentiation of IGF-II signaling by p53 mutant 249