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El estrs oxidativo representa todas las agresiones generadas por diversas molculas desviadas del oxgeno a las clulas del organismo, y las ms conocidas se denominan "radicales libres"

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Its cofactors are TPP bound to E1, lipoic acid covalently bound to lysine on E2 which accepts the hydroxyethyl carbanion from TPP as an acetyl group, coenzyme A which is substrate for E2 and accepts the acetyl group from it, FAD bound to the E3 subunit reduced by lipoamide and NAD which is substrate for E3 and reduced by FADH2 [64]