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One of the ongoing debates about this entire class of medications is whether the effects are mediated solely by weight loss and mitigation of the inflammatory consequences of energy toxicity (read: too many calories) versus other biological effects of these medications

Aim to drink at least 100 ounces of water daily during your first two weeks of treatment, spreading intake evenly throughout the day

In addition to its well-known incretin effects, GLP-1 (and its FDA-approved analogs) potently reduces food intake via its G protein-coupled receptor, GLP-1 receptor (GLP-1R)

But while on treatment, weight loss was ongoing at 48 weeks, meaning longer treatment may produce even greater reductions