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Furthermore, MC4R KO mice showed characteristics of insulin resistance, as their glucose levels were comparable to those of normal mice, despite elevated insulin levels (Table 1)

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Moreover, no side effects were found in these studies [6, 7, 8, 9]

4a), saturated and monounsaturated CE species were maintained at higher levels in the KO liver relative to the WT liver following chronic EtOH consumption (Fig