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Cost-benefit at scale: If millions use retatrutide for years, do the cardiovascular and diabetes prevention benefits outweigh the side effect burden and $15,00018,000 annual cost

As such, while short-term, targeted use appears beneficial, further studies are needed to evaluate whether prolonged application maintains its ergogenic effects or if periodic cycling of supplementation is advisable to prevent plateauing of performance benefits

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10.1038/s41598-020-77328-z 72 HosseiniS.GhadimiM.ReyhaniN.KhazaeiS.Rahmatkhah-YazdiM.Soleimani-FarsaniR.et al (2025)