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The study, Cutaneous Adverse Events Associated With GLP-1 Receptor Agonists: A FAERS Database Analysis From 2018-2024, looked at data from the FDA Adverse Event Reporting System on the following GLP-1 agonists: semaglutide, liraglutide, exenatide, and dulaglutide

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A landmark 2025 review published in Springer Nature's European Journal of Medical Research confirmed that berberine engages these AMPK-driven pathways consistently across preclinical and clinical studies, making it one of the most mechanistically rich natural compounds for metabolic dysfunction