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More studies will test its safety and efficacy over decades

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and release of Ca 2+ from intracellular Ca 2+ stores ( GLP-1 action is also mediated by -arrestin-1 ( GLP-1 exerts also proliferative and antiapoptotic, effects activating ERK and AKT signaling pathways ( CAVEOLIN--1 and DPP-IV It is well known that GLP-1 has a short plasma half-life (17 min) due to quickly degradation by Dipeptidyl Peptidase (DPP)-IV/CD26, which is an integral membrane protein widely expressed on cell surfaces and, after cleavage, present in the circulation as soluble DPP-IV ( Conclusions Although it is well recognized that Cav-1 is involved in all the steps that regulate GLP-1 function, these aspects are not fully elucidated