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When TLRs recognize PAMPs expressed by LPS, there is activation of downstream transcription factors that regulate cytokine gene expression of NF-B, generating an inflammatory response leading to GERD

Synergistic Action When GLP-1, GIP, and glucagon receptors are simultaneously activated, their effects are synergistic

This dual mechanism may offer advantages for post-bariatric patients because it addresses both appetite suppression and metabolic regulation without relying solely on gastric restriction

Some patients feel better in a few weeks, while full healing may take a few months depending on the severity of the tear