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Pfizer recently announced it decided to discontinue clinical trials of its oral GLP-1 medication for weight loss, called danuglipron, after a study participant experienced a liver injury that was potentially linked to the experimental drug

Y250 is located much farther from the disulfide bonds (Cys128-Cys206 in the hinge region between K1 and K2 domains, and Cys211-Cys288, Cys232-Cys271, and Cys260-Cys283 in the K2 domain) than the distances between Y198 and disulfide bonds, Cys149-Cys189 and Cys177-Cys201

The medications and therapeutic strategies discussed may not be suitable for everyone and can have significant risks and side effects

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