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As a matter of fact, overexpression of CRTC2 leads to higher physical interactions between CREB and CRCT2, accentuating the CREB downstream signaling, which is essential for a several cancer-associated adaptive response like glucose metabolism, cell growth, survival, immune evasion, and the maintenance of cancer stem cells

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Pathogenic GLUT9 Mutations Causing Renal Hypouricemia Type 2 (RHUC2)

275,276 Monosodium urate crystals are ingested by monocytes via phagocytosis, engaging Toll-like receptors (TLRs) such as TLR2 and TLR4