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The disruption of Golgi zinc homeostasis, whether through zinc depletion or transporter dysfunction, leads to unstacking of cisternae, vesiculation and fragmentation of the Golgi, impairing vesicle trafficking and protein sorting 73,135

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Epub 2012 Oct 10

Demonstrated Safety and Tolerability Profile 1 With RADICAVA , the most common adverse reactions were contusion, gait disturbance, and headache 1, a (see footnote) Safety profile was demonstrated in pooled placebo-controlled trials b (see footnote) in which 184 patients with ALS were administered RADICAVA (edaravone) (60 mg) in 24-week treatment cycles