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Overweight patients (BMI 25-30) may require 300-400mcg compensating for mild metabolic impairment

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DNAzymes have demonstrated well-tolerability in clinical trials targeting c-jun and EBV LMP1 proteins, because these molecules can cross the BBB following systemic injection, eliminating the need for direct brain injections 11

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Binding of FGF to FGFR4 is facilitated by the transmembrane protein Klotho , and genetic variants in this protein have been associated with colonic transit in IBS with diarrhea

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