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Folate is first converted to 5,10-methylenetetrahydrofolate through a reaction catalyzed by the enzyme dihydrofolate reductase (DHFR)

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[5] Brennan, R., Wells, J

At the 1 year follow-up, the average systolic blood pressure was 127.5 mmHg in the intensive treatment group and 135.3 mmHg in the standard treatment group