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After 72 weeks of treatment, participants on the highest dose (15 mg weekly) lost an average of 22.5% of their body weight

Before the target cells can use the fatty acids for ATP production and oxidation, the fatty acids with chain lengths of 14 or more carbons must be activated and subsequently transported into mitochondrial matrix of the cells in three enzymatic reactions of the carnitine shuttle

This occurs regardless of whether or not the patient gets thyroid hormone replacement after these therapies (which is also concerning)