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It is also pursuing commercial opportunities in the veterinary industry

Metabolic disease including insulin resistance and fatty liver is closely related and often studied in the same models

The culmination of all of these studies come to light with the finding of several (some reported and many from our group still publication pending) Larons Syndrome (congenital IGF-1 deficiency or GH insensitivity) never treated patients who underwent progression to MetS and ultimately to T2D together with diabetic retinopathy when they reached their late 30 s, [250, 251]

The combination has been associated with elevated sirtuin activity, altered adipocyte differentiation markers, and changes in muscle stem cell quiescence and proliferation in the cited preclinical literature