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A meta analysis to investigate the effect of betaine supplementation on plasma homocysteine concentration in healthy adults concludes that supplementation of at least 4g/day of betaine for a minimum of 6 weeks may lower plasma homocysteine

Enhanced collagen organization and improved cross-linking could theoretically tighten structures that have remained loose due to suboptimal original healing

JAMA 315:24242434

The GH/IGF-1 axis promotes muscle protein synthesis and lean body mass gain, enhances lipolysis and fat oxidation (reducing adipose tissue), stimulates bone formation and mineralization, supports immune function, influences cognitive function and mood, improves sleep quality and architecture, enhances skin collagen production and thickness, and modulates glucose and lipid metabolism