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DURATION-2 Study Group

A dose administered during the course of the day promotes improved sleep on the subsequent night and for several nights thereafter a temporal profile incompatible with direct sedation and consistent with a neuromodulatory mechanism acting on sleep homeostatic systems

"Because this was an observational study in a specific clinical population, randomized clinical trials are needed before GLP-1 medications can be recommended for treating addiction." The researchers plan to continue investigating the relationship between GLP-1 therapies and substance use behaviors through prospective studies that follow patients after they begin treatment, according to the study

Clin Chim Acta 431:4651 Kato GJ, Piel FB, Reid CD, Gaston MH, Ohene-Frempong K, Krishnamurti L, Smith WR, Panepinto JA, Weatherall DJ, Costa FF, Vichinsky EP (2018) Sickle cell disease