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Appropriate for patients struggling with excess weight, persistent hunger, metabolic dysfunction, or difficulty achieving durable weight loss through diet and exercise alone Dosing / Titration Treatment begins with a low dose that is gradually increased over several weeks to improve tolerability and minimize gastrointestinal side effects

Increased levels of NEFAs in the liver are mainly the result of: (i) stimulated lipolysis from visceral fat (hormone-sensitive lipase cannot be sufficiently downregulated)